Van Brussel, M., Takken, T., Uiterwaal, C., Pruijs, H. J., Van der Net, J., Helders, P. J. M., et al. (2008). Physical training in children with osteogenesis imperfecta. Journal of Pediatrics, 152, 111-116.

The purpose of this study was to examine the effects of a physical activity program on exercise capacity, muscle force, and subjective fatigue levels in children with mild to moderate forms of osteogenesis imperfecta (OI). Thirty-four children from 8 to 18 years of age were randomly assigned to either 12 weeks of graded exercise intervention or usual care. Outcome measures included exercise capacity (VO2peak), maximal working capacity (Wmax), muscle force, subjective fatigue, perceived competence, and health-related quality of life (HRQoL). Results showed that VO2peak, relative VO2peak, Wmax, and muscle force were significantly improved while subjective fatigue decreased significantly.

For the full abstract, go to http://www.ncpad.org/603/2555/Physical~ Training~in~Children~with ~Osteogenesis~Imperfecta~.