Activities are held on a weekly basis on the grounds of the Greenspring Campus of Kennedy Krieger Institute. Off-site programming may include participation in local, regional, national and international athletic competitions. Special activity camps in golf, bicycling, and sled hockey are held on campus or at local university/recreational facilities. Activities scheduled for a particular semester may vary and can include both beginner and advanced training.

The Physically Challenged Sports and Recreation Program is open to individuals aged 2 - 21 who experience physical challenges and exhibit cognitive skills at or near appropriate developmental levels. Participants are interviewed along with their families to determine appropriateness for participation. Participants must demonstrate the ability to follow one-step verbal directions and to respond to verbal social and behavioral cues necessary for safe, independent participation in group activities. Admission to the program is also determined based on the availability of space in a particular program. Determination of eligibility is made during the interview by the program's co-directors.