The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) invites center program project applications for the Learning Disabilities Research Centers Program, hereafter termed Program. The Program will focus on generating new scientific knowledge to inform our understanding of learning disabilities and comorbid conditions. The request invites both foundational and translational, transdisciplinary research examining issues related to etiology, classification and definition of, and prevention and remediation of learning disabilities impacting listening, speaking, reading, writing and mathematics with an emphasis on comorbid conditions. The P50 mechanism allows for richly integrative, multi-method approaches to examining research topics focusing on learning disabilities that are not feasible through standard research mechanisms. Applicants should propose inter-disciplinary, coordinated programs of research that demonstrate cohesion and synergy across research subprojects and cores.