This RFA will provide supplemental funding to Prevention Research Centers, to design, test, and disseminate effective prevention research strategies in the areas of chronic disease prevention and control in the areas of: Access to Health Services, Adolescent Health, Cancer, Educational and Community-Based Programs, Immunization and Infectious Diseases, Injury and Violence Prevention, Older Adults, Quality of Life and Well-Being, and Sexually Transmitted Diseases. This funding opportunity announcement (FOA) solicits cooperative agreement applications from applicant organizations that propose to (1) focus on the major causes of death and disability, with an emphasis on underserved and vulnerable populations (2) improve public health practice through community-based participatory research, and (3) design, test, disseminate, or translate effective public health programs at the state and community level.