The goal of the NIH Transformative Research Awards initiative is to provide support for collaborative investigative teams or individual scientists who propose transformative research projects, which, if successful, would have a major impact in a broad area of biomedical or behavioral research. To be considered transformative, projects must have the potential to create or overturn fundamental scientific paradigms through the use of novel approaches, to transform the way research is conducted through the development of novel tools or technologies or to lead improvements in health through the development of highly innovative therapies, diagnostic tools, or preventive strategies.