The medication regimen known as highly active antiretroviral therapy (HAART) or combination drug therapy has the potential to prolong life through suppression of viral replication if adherence is maintained at a satisfactory level. Failure of medication treatment adherence can have devastating results, including continued replication of the virus, weakened immune system function, and increased susceptibility to opportunistic infections that could potentially lead to death. It is important to understand the barriers that people with HIV/AIDS experience when adhering to medication regiments. Utilizing a problem solving approach (MAPS) for barriers related to adherence of medication may improve the quality of life in people with HIV/AIDS, especially when combined with exercise.