While antiretroviral medications have allowed many people with HIV/AIDS to live longer, fuller lives, the demand of balancing complex medication regimens with activities of daily life along with managing side effects has led many people to stop taking medications, skip doses, or interrupt their regimen. According to Paterson et al (2000), a high proportion of doses (95%) must be taken in order to maintain suppression of viral replication. Even minor changes or short-term interruption of the regimen have been shown to increase viral load with the potential of mutation of viral strains that are resistant to medication. Once resistance to a drug occurs, benefit from that drug as well as similar drugs in that class is jeopardized. The existence of resistant forms of the HIV virus poses a threat to the public if spread due to the limitations in drug treatment options that are potentially available to suppress the replication of the mutated virus.