Duchenne muscular dystrophy (DMD) is a genetically X-linked disorder of skeletal muscle characterized by progressive muscle atrophy. DMD is caused by various mutations in the DMD gene and result in a loss of the skeletal muscle protein dystrophin, which leads to a degradation of skeletal muscle. Animal models encompass the majority of the literature surrounding exercise and DMD. There is no cure for DMD, but sub-maximal non-muscle damaging exercise may improve the quality of life in persons with DMD. Safe exercises for persons with DMD include: flexibility exercise (passive/active), low-impact aerobic exercise (cycling or swimming), or isokinetic and uni-directional strength exercise (concentric-only or eccentric-only). Due to the lethal nature of DMD, exercise prescription should be tailored to meet the demands of each individual to avoid possible adverse effects of exercise.